Art21 is governed by a Board of Trustees that provides guidance and oversight for the organization's programs and activities. - David Howe, Chairman
- Migs Wright, President
- Jean-Yves Noblet, Treasurer
- Robert Crothers, Secretary
- Constance Caplan
- James Cohan
- Susan Dowling
- Glenn DuBose
- Albert Gottesman
- Jeanne Greenberg Rohatyn
- Bruce Grivetti
- Oliver Herring
- Howard Karshan
- Samuel Ketcham
- Paul Pfeiffer
- Pamela Sanders
- Ed Sherin
- Shahzia Sikander
- James Sollins
- Susan Sollins
- Ellen Stern